Zoliflodacin (b)

Research use only, not for human use.

Zoliflodacin?is a new antibiotic that inhibits DNA biosynthesis.

Zoliflodacin?is a new antibiotic that inhibits DNA biosynthesis.

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Animal Model:MCF-7 human breast cancers growing in miceDosage:56 mg/kg Administration:IV; 2 daily; 49 days Result:Alone was able to produce significant (>50%) tumor regression. This regression was stabilized when combined with daily dosing with the oral HDAC4 inhibitor, Tasquinimod (10 mg/kg/d; oral).Animal Model:BALB/c miceDosage:67 mg/kg (Pharmacokinetic Analysis)Administration:IV; a single dose Result:Had a half-life of 4.9 hours.

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Others

Other Targets

Others

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1245732-48-2

1409.5

C66H100N6O27?

>98% (HPLC)

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CCCCCCCC(=O)O[C@H]1[C@H]2C(=C([C@@H]1OC(=O)/C(=C\C)/C)C)[C@H]3[C@]([C@H](C[C@]2(C)OC(=O)C)OC(=O)CCCCCCCCCCCNC(=O)C[C@@H](C(=O)N[C@@H](CCC(=O)N[C@@H](CCC(=O)N[C@@H](CCC(=O)N[C@@H](CCC(=O)O)C(=O)O)C(=O)O)C(=O)O)C(=O)O)N)([C@](C(=O)O3)(C)O)O

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(-20℃)

With Ice Pack

≥ 2 years